This study was conducted to investigate effect of Bifenthrin on gravimetric parameters in Wistar rats. This study was conducted in eight week old Wistar rats. Twenty four male and twenty four female wistar rats were randomly divided into four different groups, Group I, II, III and IV comprising six male and six female rats. Group I served as vehicle control and treated with corn oil only. Group II, III and IV served as treatment group and treated with Bifenthrin at dose rates of 2.5, 10 and 20 mg/kg body weight respectively for 28 days daily in corn oil. Body weight was recorded on day 0, 7, 14, 21 and 28. Body weight change and feed consumption was calculated on weekly basis. After completion of 28 days of exposure period liver, kidney, heart, spleen, lungs, thymus and adrenals absolute and relative organ weight estimation was performed. Significant decrease in body weight and body weight gain was observed in treated group of animals in both male and female rats. Significant decrease in feed consumption was observed during treatment in treated group of animals in both male and female rats. Absolute and relative organ weight estimation revealed, significant increase in absolute liver and kidney weight in treatment group in both male and female rats. On the other hand significant decrease in absolute adrenal weight was observed in treatment group. There was significant increase in relative liver, kidney and heart weight observed in treatment group of male rats. Similarly significant increase in relative liver and kidney weight was observed in female treatment group of animals. Based on these study findings, it was concluded that Bifenthrin significantly altered the body weight, feed consumption, absolute and relative organ weight in wistar rats at the dose level tested.
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